Second primary malignancies in oral tongue cancer: A Surveillance, Epidemiology, and End Result–based analysis evaluating the basic characteristics, survival outcomes, and predictive factors

The purpose of this study is to evaluate the risk developing a second primary malignancy (SPM) in oral tongue cancer (OTC) patients, and identify characteristics survival outcomes OTC patients with an SPM. Patients first were identified from Surveillance, Epidemiology, End Result (SEER) database, further divided into only one (OOPM) group SPM group. Baseline between two groups compared. Furthermore, Fine Gray subdistribution hazard model was utilized investigate cumulative patients. Then, multivariate competing-risk performed explore predictors. had older age lower tumor stage than those OOPM Moreover, proportion receiving surgery significantly higher that Lung most common site SPMs whole In male prostate, while female it breast. lung bronchus worst overall survival. Finally, age, sex, ventral surface anterior 2/3 tongue, localized diseases, administration considered as predictors survivors high SPM, subsequent important COD. Careful monitoring warranted due SPM-specific mortality.